Biosimilars Advisory Service

March 2014

Biosimilars Advisory Service: Corporate Strategies

  • Pages:161
  • Tables:25
  • Figures:60
  • Citations:N/A
  • Drugs:22
  • Interviews:630

Introduction:

In order to maximize potential commercial return, biosimilar developers must adopt clear and effective strategies that leverage their internal capability and potentially capture the expertise of partners. Partnership activity in the biosimilar space increased 34% in 2013 compared with 2012, with 34 new partnerships formed in 2013 compared with 26 in 2012. Biosimilar developers need to assess the optimal strategies to implement early in product development to differentiate their biosimilar product from rival biosimilars and from the reference biologic. Companies that market reference brands are at risk of losing considerable revenue and need to adopt defensive strategies to limit or offset sales erosion. For both of these types of market players, determining the optimal strategy is challenging given the highly dynamic biosimilars environment and the need to factor in the impact of the evolving perceptions of key stakeholders such as physicians and payers.

Questions Answered in This Report:

  *   We have identified 135 partnerships that have been formed for the development of biosimilar biologics across various geographies, globally. What types of strategic partnerships have been forged for the development of biosimilars? What are the regions of relevance for biosimilar strategic alliances?  Which biologic classes are the most common targets among biosimilar strategic partnerships? How are regional biosimilar developers establishing a regional and global footprint? How are public-private productive development partnerships (PDPs) driving biosimilar development in Brazil?

  *   Biosimilar manufacturers can consider robust marketing campaigns to promote biosimilar adoption. To what extent are physicians concerned about the level of similarity between the cell line used for a biosimilar compared with a branded biologic? To what extent will marketing efforts of biosimilar manufacturers influence prescribing practices and inclusion on formularies? What types of biosimilar marketing exposure will be most influential in guiding physicians’ selection of one biosimilar over another?

  *   Multiple innovative branded biologic companies are at risk from significant biosimilar erosion across the seven major pharmaceutical markets. Which innovator companies stand to lose the greatest proportion of revenue as a result of biosimilar competition?

  *   Innovator biologics companies can utilize multiple defensive strategies to better compete with biosimilars. Strategies include adopting flexible pricing and novel value-add services, promotion of perception of greater reliability, and developing follow-on biobetters. To what extent will implementation of these strategies be successful in resisting erosion? To what extent are physicians and payers concerned about manufacturers guaranteeing a robust supply chain for biosimilars? How will counter-detailing strategies from branded biologic innovators influence physician prescribing preference?

Scope:

Company strategies: Case studies describing biosimilar manufacturer’s strategies to promote biosimilar adoption and branded biologic innovator manufacturer’s strategies to limit or offset sales erosion biosimilar erosion.

Markets covered: Global assessment of strategic alliances for the development of biosimilars.

Primary research: Surveys with 560 specialist physicians across six different specialties in the United States and Europe. Surveys with an additional 60 U.S. managed care organization directors and 10 telephone interviews with key European payer advisors. Primary market research with key stakeholders to assess the following:

- Perceptions of biosimilar marketing campaigns.

- How postmarketing studies influence uptake of biosimilars.

- Extent to which counter-detailing influences stakeholder perceptions.

- Attitudes toward host-cell species for biosimilar development.

Biosimilar Strategic Alliances Deliverable: Assessment of 135 biosimilars-focused partnerships across nine drug classes and 22 molecules.

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Mentioned in this report:

  • - 3SBio
  • - Abdi Ibrahim
  • - Accelsiors
  • - Aché
  • - Actavis
  • - AET BioTech
  • - Alteogen
  • - Amega Biotech
  • - Amgen
  • - ApoLife
  • - Apotex
  • - Aprogen
  • - ASKA Pharmaceutical
  • - ATMI
  • - Avesthagen
  • - Baxter
  • - Bergamo
  • - Bharat Serums and Vaccines
  • - Binex
  • - Biocad
  • - Biocon
  • - Biogen Idec
  • - Biogenomics
  • - Biolab
  • - BioNovis
  • - BioPartners
  • - Bioton
  • - BioTrion
  • - BioXpress Therapeutics
  • - Boehringer Ingelheim
  • - Boston Oncology
  • - Cangene
  • - Catalent Pharma
  • - CCM Pharmaceuticals
  • - Celerion
  • - Cellectis
  • - Celltrion
  • - Charles River Laboratories
  • - Chiltern International
  • - China Chemical and Pharmaceutical
  • - CinnaGen
  • - Cipla
  • - CoGenesys
  • - Coherus Bioscience
  • - Covance
  • - Cristalia
  • - Curaxys
  • - Cyplasin Biomedical
  • - Daewoong Pharmaceutical
  • - Daiichi Sankyo
  • - Dem Pharmaceuticals
  • - Desano
  • - Dexa Medica
  • - Dong-A
  • - Dr. Reddy's
  • - Eden Biodesign
  • - Egis
  • - Eli Lilly
  • - Elona Biotech
  • - EMS
  • - EPIRUS Biopharmaceuticals
  • - Europharma
  • - ExSar
  • - Finox Biotech
  • - Fosun Pharma
  • - Fuji Pharma
  • - Fujifilm
  • - GE Healthcare
  • - Gedeon Richter
  • - GeneMedix
  • - GlaxoSmithKline
  • - Gleneagles
  • - Gleneagles Clinical Research International
  • - GlycoFi
  • - Glycotype
  • - Green Cross
  • - GTC Biotherapeutics
  • - Handok Pharmaceuticals
  • - Hanmi Pharmceuticals
  • - Hanwha
  • - Harlan Laboratories Contract Research Services
  • - Harvest Moon Pharmaceuticals
  • - Henlius Biopharmaceuticals
  • - Hetero Drugs
  • - Hexal
  • - Hikma
  • - Hospira
  • - Hypermarcas
  • - iBio
  • - ICON
  • - Inno Biologics
  • - Insmed
  • - Instituto Vital Brazil
  • - Intas Biopharmaceuticals
  • - Ipsen
  • - ISU Abxis
  • - JCR Pharmaceuticals
  • - Kemwell Biopharma
  • - Kissei Pharmaceutical
  • - Kymos
  • - Kyowa Hakko Kirin
  • - Lentigen
  • - LG Life Sciences
  • - Lonza
  • - Lupin
  • - Mabion
  • - MabPharm
  • - Mabxience
  • - Macrogenics
  • - Medicago
  • - Medice Arzneimittel Putter
  • - MedImmune
  • - Meiji Seika
  • - Merck & Co
  • - Merck KGaA
  • - Minapharm Pharmaceuticals
  • - MJ Group
  • - Mochida
  • - Momenta
  • - Mycenax
  • - Mylan
  • - Natco Pharma
  • - National Cancer Institute
  • - National Engineering Research Center of Antibody Medicine of China
  • - NeuClone
  • - Nichi-Iko
  • - Nippon Kayaku
  • - Nipro Pharma
  • - Nuron Biotech
  • - Oli Med
  • - Oncobiologics
  • - ORF Genetics
  • - Orygen Biotechnology
  • - PanGen Biotech
  • - PanPharmaceuticals
  • - Pantheon
  • - Parexel
  • - Parilis Biopharmaceuticals
  • - Perrigo
  • - Pfenex
  • - Pfizer
  • - Phage Pharmaceuticals
  • - Pharmaceutical Product Development
  • - PharmaNet
  • - PharmaPraxis
  • - PlantForm
  • - PLIVA
  • - PRA
  • - Probiomed
  • - ProCognia
  • - ProMetic Biosciences
  • - Protagen
  • - Protalix Biotherapeutics
  • - Quantum Tessera
  • - Quintiles
  • - Ranbaxy
  • - Ratiopharm
  • - Reliance Life Sciences
  • - Ricera
  • - Richter-Helm Biologics
  • - Samsung
  • - Sandoz
  • - Sanofi
  • - Shanghai Celgen
  • - Shanghai CP Guojian
  • - Shenzhen Main Luck
  • - Spectrum Pharmaceuticals
  • - Spinnovation Biologics
  • - STADA
  • - STC Biologics
  • - Synthon
  • - Teva
  • - TTY Biopharm
  • - UMN Pharma
  • - Uni Targeting Research
  • - USV Biologics
  • - Viropro
  • - Watson
  • - Wockhardt
  • - WuXi Apptec
  • - Xcellerex
  • - Yakult
  • - Zenotech
  • - Zydus Cadilla
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